CompARE
Welcome to CompARE - Designing feasible clinical trials
What is CompARE?
CompARE is an initiative inspired to provide help on issues relating to trials with composite endpoints. CompARE may be used as a tool for calculating the elements needed in the planning phase of clinical trials involving composite endpoints.
Shiny Apps
CompARE is split into two apps for time-to-event and
binary endpoints, respectively. They are implemented with the Shiny R
package. With its user-friendly interface, CompARE allows to input the
main parameters included in the trial -such as the treatment effect on
the components of the composite endpoint, and its frequencies of
occurrence- and helps provide power and sample size calculations among
others.
R Package - CompAREdesign
You can also find the R-package version of CompARE in CRAN CompAREdesign.
It has been designed to calculate the required sample size in randomized clinical trials with composite endpoints. This package also includes functions to calculate the probability of observing the composite endpoint and the expected effect on the composite endpoint, among others.
